《美國末日》這款遊戲的原聲想必大家期待已久，這款遊戲的音樂是由音樂大師Gustavo Santaolalla指導製作。《斷背山》電影的音樂主要由他負責指導。下麵是《美國末日》曲目詳細介紹。
預定於6月14日發售的頑皮狗新作《美國末日》日前公開了多達30首遊戲的原聲供玩家試聽。
曲目列表：
The Quarantine Zone (20 Years Later)
The Hour
The Last of Us
Forgotten Memories
The Outbreak
Vanishing Grace
The Hunters
All Gone
Vanishing Grace (Innocence)
By Any Means
The Choice
Smugglers
The Last of Us (Never Again)
The Last of Us (Goodnight)
I Know What You Are
Home
Infected
All Gone (Aftermath)
The Last of Us (A New Dawn)
All Gone (No Escape)
Vanishing Grace (Childhood)
The Path
All Gone (Alone)
Blackout
The Way It Was
Breathless
The Last of Us (You and Me)
All Gone (The Outside)
The Path (A New Beginning)
Returning
喜歡 
高興
鬼臉
嗬嗬
無聊
傷心
